Seminars & Workshops
Bias and Confounding in Clinical Research

After completing this lecture, you will be able to:

  • Define the major types of epidemiologic bias – confounding, selection bias, and information bias
  • Identify ways to prevent bias
  • Explain the differences between precision and validity
  • Discuss the framework for assessing valid statistical association using alternative explanations of chance, bias and confounding
  • Interpret p-values and confidence intervals to assess the role of chance
  • Distinguish between external validity (generalizability) and internal validity
  • Identify strategies to control for potential confounders.

Taught by: Jessica Paulus, ScD

Seminars & Workshops
Concepts of Hypothesis Testing

After completing this lecture, you will be able to:

  • Define hypothesis testing
  • Explain the differences between a null and alternative hypothesis
  • Describe the purpose of statistical testing
  • Describe the relationship between hypothesis testing and p-value
  • Interpret results of chi-square and t-test.

Taught by: Lori Lyn Price, MAS.

Seminars & Workshops
Developing a Study Protocol

After completing this lecture, you will be able to:

  • Define a research protocol
  • Explain the difference between a protocol and a proposal
  • List the steps in planning a study
  • Identify potential issues in implementing a protocol
  • Describe the aspects of subject safety in a study
  • Explain why subject confidentiality is key to a study.

Taught by: Tammy Scott, PhD.

Seminars & Workshops
Evaluating Scientific Journal Articles

View the slides for this seminar (PDF).

View the article that will be discussed during this seminar (PDF).

 

What makes a journal article successful?

Join us for Evaluating Scientific Journal Articles and learn the questions you should ask yourself, whether reviewing journal articles or writing your own. This interactive seminar will be presented by Lori Lyn Price, MAS, Statistician in the Biostatistics, Epidemiology, and Research Design (BERD) Center.

By the end of this seminar you will be able to:

  • List the questions you should ask yourself when evaluating a scientific journal article.
  • Identify the specific, testable hypothesis of the paper.
  • Identify what type of study design was used.
  • Evaluate whether the results of the study were affected by bias.
  • Explain why this study was important, what it added to the literature, or how it changed health practice.
  • Appraise the compatibility of the conclusions of the study with the study objectives.

Details

Thursday, April 28th, 1:00 – 2:30PM
Arthur M. Sackler Center for Medical Education, Room 114
145 Harrison Avenue, Boston

Or via live, interactive webcast (a link will be provided to those who register).

Registration

All are welcome to attend. Please register online.

Prior to the seminar, you will be asked to read a journal article. The scientific journal article will be emailed to you after you register for the seminar.

Seminars & Workshops
Formulating Research Questions, Hypotheses and Objectives

After completing this lecture, you will be able to:

  • Outline approach to formulating structured, clinically-relevant research questions
  • Highlight importance of evidence based approach to critically evaluating scientific literature
  • Review existing tools and resources
  • Review relationship between types of clinical questions and study design
  • Explain the relationship between research questions and objectives, specific aims, hypotheses, power/sample size, and statistical analysis.

Taught by: Kahsi A. Smith, PhD.

Seminars & Workshops
How Many Subjects Do I Need for My Study?

After completing this lecture, you will be able to:

  • Explain the role of chance in sampling a population
  • State the steps in hypothesis testing
  • Identify types of statistical error
  • Describe what parameters affect sample size
  • List online resources for sample size calculators
  • Perform a basic sample size calculation using an online tool.

Taught by: Jessica K. Paulus, ScD.

Seminars & Workshops
Introduction to Study Design

After completing this lecture, you will be able to:

  • Explain the importance of looking at the totality of evidence in developing and assessing a research question
  • Define an experimental study design strategy
  • Define an observational design strategy
  • Identify the strengths and challenges of retrospective and prospective studies
  • State the limitations of observational studies
  • Express the differences between cohort and case-control studies
  • Describe what a randomized clinical trial is
  • Explain how to limit confounding bias
  • Describe the strengths and limitations in doing interventional studies.

Taught by: Jessica Paulus, ScD.

Seminars & Workshops
Linear and Logistic Regression

After completing this lecture, you will be able to:

  1. Determine when regression should be used
  2. Describe the differences between linear and logistic regression
  3. Discuss basic assumptions of linear and logistic regression
  4. Identify the advantages of regression models
  5. Interpret the results of regression models.

Taught by Lori Lyn Price, MAS

Seminars & Workshops
Modeling Time-to-Event Outcomes

After completing this lecture, you will be able to:

  • Define survival analysis
  • Explain how time-to-event data is different from other data
  • Discuss the differences between Kaplan-Meier curves and Cox regression
  • Identify a Kaplan-Meier curve and a Cox regression in a journal article
  • Describe how survival estimates are calculated

Taught by Robin Ruthazer, MPH,

Seminars & Workshops
Pitfalls in Statistical Analysis

After completing this lecture, you will be able to:

  • Discuss how statistical significance does not equal clinical significance
  • Describe common mistakes about null hypothesis testing
  • Explain the importance of matching your analysis to the study design
  • Determine three considerations for controlling for multiple testing
  • Explain how to handle missing data
  • Identify statistical considerations in an actual published study.

Taught by: Lori Lyn Price, MAS