The Trial Innovation Network (TIN) is a national collaborative funded by the National Institutes of Health (NIH) and consisting of the hubs of the national CTSA Consortium, the three Trial Innovation Centers (TICs), and a Recruitment Innovation Center (RIC).

The mission of the TIN is to support the development and conduct of multi-site clinical trials at CTSA institutions. The TIN focuses on operational innovation, operational excellence, and collaboration. To facilitate the quality and success of multi-site trials, the TIN offers investigators the opportunity to request a consultation or access specific resources for study conduct, whether funded or in the planning stages.

Requests for TIN consultations or services must first be reviewed and approved by the sponsoring CTSA before they are submitted by investigators. Investigators will hear from the TIN within five days, at which time an initial phone call is scheduled. The proposal process can be viewed here. All investigators will be contacted.

Resources and Services

TIN resources and services include:

  • Consultations on study design, budget and feasibility
  • Single IRB support, resources and tools, and web-based platform (IREx)
  • Standard agreements
  • Expression of interest outreach
  • Innovations in clinical trial effectiveness
  • Assessments of study recruitment and retention strategies and recruitment feasibility
  • Evidence-based recruitment and retention plans/materials
  • EHR-based cohort assessment for informing study design and site selection
  • Community engagement studio for meaningful involvement of diverse groups of stakeholders in the planning and implementation of research

For more information, please visit the Initial Consultation page here.

Who is eligible?

Investigators from Tufts CTSI partner institutions who are planning multi-site clinical trials or studies may be eligible to submit a request for TIN services. Prior to submitting a proposal to the TIN investigators must:

1. Leverage the local CTSA program resources
2. Discuss the proposal with the Tufts CTSI MCRC liaison team
3. Receive approval from the CTSA Program Hub Principal Investigator

Proposal Submissions

The Trial Innovation Network is accepts multi-site submissions of requests for research proposal support on an ongoing basis. Use the links below to learn about the TIN proposal process, submission instructions, and frequently asked questions (FAQs).

TIN Proposal Process and Submission Instructions

TIN Proposal Process FAQs


If you are affiliated with Tufts CTSI, please submit a request for support here. Please be sure to select General Consult and use the text box to describe your Trial Innovation Network request.

Jonathan Davis, MD

Marisha Palm, PhD
Program Director