The diagram depicts the six phases in the Translational Spectrum of Comparative Effectiveness Research:

  1. Evidence Prioritization: Qualitative and Quantitative Elicitation
  2. Evidence Generation: Randomized Controlled Trials, Registries, Observational Studies, and N-of-1 Trials
  3. Evidence Synthesis: Systematic Reviews and Meta-Analysis
  4. Evidence Interpretation and Integration: Cost-Effectiveness Analysis and Decision Analysis
  5. Dissemination and Application: Guidelines, Policy, Social Sciences, and Implementation Science
  6. Feedback and Assessment: Qualitiative Elicitation, Data Monitoring, and Quality Monitoring and Measurement

Each phase relates back to the previous phase(s), and involves researchers, research organizations, and stakeholders.