CANCELLED
Center for Quantitative Methods and Data Science Seminar: Tanya Karagiannis, MS

This event is cancelled. We apologize for any inconvenience.

The Center for Quantitative Methods and Data Science, in partnership with the Biostatistics, Epidemiology and Research Design (BERD) Center and the Data-Intensive Studies Center (DISC) will host a Zoom seminar series on a Wednesday each month from 2:00-3:00PM.

The November session on Wednesday, November 11 will feature Tanya Karagiannis, MS. She will give a talk titled Analysis of Single Cell Transcriptomics Data as it Relates to Aging and Longevity.

Abstract

Studies of aging have shown a gradual decline in the immune system, such that people experience age-related disabilities and diseases as well as differences in immune population composition and functions over time. However, a rare population of individuals who reach 100 years of age known as centenarians, experience delay in age-related disabilities and diseases and in fact live the majority of their lives in good health. In order to investigate how centenarians delay and defy aging, we utilize single cell transcriptomic methods to investigate longevity related differences in the peripheral blood immune system of centenarians. Single cell level transcriptomic data has allowed for the profiling of thousands of cells to characterize cell states and populations in specific tissues. More specifically, these methods can be used to identify rare populations and assess transcriptional similarities and differences within a population of cells. We describe integrated analyses using four single cell RNA-sequencing datasets that we conducted to investigate compositional and gene expression differences in immune populations of centenarians and younger age controls (20-80 years). Early findings demonstrate gene expression differences between centenarians and younger age controls that are specific to populations of cells. We also find centenarians not only have cell type specific compositional differences but overall have more cell type diversity than younger age controls.

Faculty

Tanya Karagiannis is a Research Assistant at Tufts Medical Center in the Institute for Clinical Research and Health Policy Studies, working with Dr. Paola Sebastiani. She has an MS in Bioinformatics from Boston University where she is also continuing her PhD in Bioinformatics under the advisement of Dr. Paola Sebastiani and Dr. Stefano Monti. Her research focus is in the application and development of single cell transcriptomic methods utilizing machine learning and Bayesian statistics, with interest in multi-omics as well.

Details

Date: Wednesday, November 11, 2020, 2:00-3:00PM

Location: Zoom video conference.

Registration

To receive the link to the Zoom video conference, please register here.

 

CANCELLED
22nd Annual Clinical and Translational Science Graduate Program Symposium

CANCELLED

Due to the ongoing COVID-19 pandemic, this event is cancelled for 2020. We regret any inconvenience this may cause, and look forward to hosting the Symposium in 2021.

 

Overview

The 22nd Annual Clinical and Translational Science (CTS) Graduate Program Symposium will be Friday, May 22, 8:00AM-1:00PM at Tufts Medical Center, Wolff Auditorium, 800 Washington Street, Boston, MA.

This year’s keynote speaker is Robert W. Yeh, MD, MSc, MBA, Director of the Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology at the Beth Israel Deaconess Medical Center, and Associate Professor of Medicine at Harvard Medical School.

The event will also feature presentations and posters by students enrolled in the CTS Graduate Program, and the 2020 Clinical and Translational Science Poster Competition.

Schedule of Events

  • 7:30AM: Breakfast
  • 8:00AM: Welcome
  • 8:15AM: Presentations by Graduating Students
  • 9:45AM: Poster Session and 2020 Clinical and Translational Science Poster Competition
  • 10:15AM: Group Photo in Atrium, Main Lobby
  • 10:30AM: Presentations by Graduating Students
  • 11:45AM: Closing Remarks
  • 12:00PM: Keynote Lecture/Medical Grand Rounds