2009

2010

2011

2012

2013

2014

2015

2016

2017

2009 Pilot Studies Grant Awardees

Eleven projects were awarded in 2009.

 

PI: Lisa Freeman, DVM, PhD, DACVN, Professor

TITLE: Gene-Nutrient Interactions in Hypertrophic Cardiomyopathy

 

PI: Jonathan Garlick, DDS, PhD, Professor and Director of Cancer Biology and Tissue Engineering

TITLE: Induced Pluripotent Stem Cells to Treat Skin Disease

 

PI: Iris Zamir Jaffe, MD, PhD, Assistant Professor

TITLE: Mechanisms of Cardiac Fibrosis in Hypertrophic Cardiomyopathy

 

PI: Miaofen G. Hu, MD, PhD, Instructor of Medicine

TITLE: Role of CDK6 in T Cell Development and Cancer

 

PI: Brigitte T. Huber, PhD, Professor

TITLE: The Role of DPP2 in Controlling the Insulin Metabolism

 

PI: Eric Miller, PhD, Professor

TITLE: Image Processing Tool for Quantification of Knee Cartilage in MR1 Data Stacks

 

PI: Gordon Huggins, MD, Assistant Professor

TITLE: Genetic Modifiers of Hypertropic Cardiomyopathy

 

PI: Rocco Ricciardi, MD, MPH, Assistant Professor

TITLE: Transmission and Clustering of C.difficile colitis in U.S. Acute Care Hospitals

 

PI: Jayanthi Mistry, PhD, Associate Professor

TITLE: CBPR Approach in Assessing Programs for Youth From Immigrant Families

 

PI: Katherine L. Tucker, PhD, Senior Scientist

TITLE: Formative Research for the Design of a Multi-Level Cadiovascular Disease Prevention Intervention in Puerto Rican Adults

 

PI: Carol A. Kumamoto, PhD, Professor

TITLE: Effect of Diet on Intestinal Colonization by Candida Albicans

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2010 Pilot Studies Grant Awardees

Twelve projects were awarded in 2010.

 

PI: Daniel Jay, PhD, Professor of Physiology, Tufts University School of Medicine

Co-PI: Julian Wu, MD, Professor of Neurosurgery, Tufts University School of Medicine

TITLE: Inhibiting Semaphorin 3A-Neuropilin-1-mediated GBM Dispersal

GRANT TYPE: Catalyst

 

PI: Charlotte Kuperwasser, PhD Associate Professor of Anatomy and Cell Biology, Tufts University School of Medicine

Co-PI: Grace Gill, PhD, Associate Professor, Tufts University Sackler School of Graduate Biomedical Sciences

TITLE: Regulation of Breast Progenitor and Tumor Cell Phenotype by a BRCA1-Slug-LSD1 Pathway

GRANT TYPE: Catalyst

 

PI: David Thorley-Lawson, PhD, Professor of Pathology, Tufts University School of Medicine

Co-PI: Andreas Klein, MD, Assistant Professor of Medicine, Tufts University School of Medicine; IRB Chair, Tufts Medical Center

TITLE: Whole Genome Sequencing of the Epstein-Barr Virus and Post-transplant Lymphoproliferative Disease Tissue

GRANT TYPE: Planning

 

PI: Janet E. Forrester, PhD, Associate Professor of Public Health and Community Medicine, Tufts University School of Medicine

Co-PI: Hoon Ji, MD, PhD Assistant Professor, Tufts University School of Medicine

TITLE: The Effect of Genetic Variants on the Relation Between Fatty Liver and Cardiovascular Disease Risk in HIV Infection

GRANT TYPE: Catalyst

 

PI: Brent Cochran, PhD, Professor of Physiology, Tufts University School of Medicine

Co-PI: Doug Jefferson, PhD Associate Professor, Tufts University Sackler School of Graduate Biomedical Sciences

TITLE: Identification of Novel Biomarkers of Glioblastoma Stem Cells

GRANT TYPE: Catalyst

 

PI: Li Zeng, PhD, Assistant Professor of Anatomy and Cellular Biology, Tufts University School of Medicine

Co-PI: Elizabeth Matzkin, MD, Department of Orthopedics, Tufts Medical Center

TITLE: Novel Strategies to Enhance Host-integration in Cartilage Repair

GRANT TYPE: Catalyst

 

PI: Elizabeth Tanefis, BA, Program Associate, Environmental Health Department, Health Resources in Action (HRIA)

Co-PI: Doug Brugge, PhD, MS, Professor of Public Health and Community Medicine, Tufts University School of Medicine

TITLE: An Investigation of Multiple In-Home Health Hazards in Boston-based Family Childcare Providers Facilities

GRANT TYPE: Planning

 

PI: Lewis M. Cohen, MD, Professor of Psychiatry, Tufts University School of Medicine; Department of Psychiatry, Baystate Health

Co-PI: John Griffith, PhD, Associate Professor of Medicine, Tufts University Sackler School of Graduate Biomedical Sciences

TITLE: Renal Supportive Care

GRANT TYPE: Catalyst

 

PI: Scott Preston, PhD, Director of Program Improvement, Compliance, and Technology, The Walker School and Home

Co-PI: Dominic Hodgkin, PhD, Associate Professor, Heller School for Social Policy and Management, Brandeis University

TITLE: Examining Pediatric Psychotropic Medication Use in Residential and Day Treatment Facilities

GRANT TYPE: Planning

 

PI: John Leung, MD, Division of Gastroenterology, Tufts Medical Center

Co-PI: Peter Bonis, MD, Division of Gastroenterology, Tufts Medical Center

TITLE: Exhaled Nitric Oxide as a Non-invasive Surrogate for Eosinophilic Esophagitis

GRANT TYPE: Planning

 

PI: Chenchen Wang, MD, MSc, Division of Rheumatology, Tufts Medical Center

Co-PI: John Wong, MD, Chief, Division of Clinical Decision Making, Tufts Medical Center

TITLE: Cost-effectiveness of Tai Chi Mind-body Exercise for the Treatment of Fibromyalgia

GRANT TYPE: Catalyst

 

PI: Roula Choueiri, MD, Center for Children with Special Needs, Floating Hospital for Children at Tufts Medical Center

Co-PI: Sheldon Wagner, PhD, Community-based Child Developmental Psychologist

TITLE: Validation and Reliability of Play-based Tests in the Clinical Evaluation of Toddlers with Autism Spectrum Disorders (ASD)

GRANT TYPE: Planning

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2011 Pilot Studies Grant Awardees

Thirteen projects were awarded in 2011.

 

Co-PIs: Guo-Fu Hu, PhD, Associate Professor, Molecular Oncology Research Institute, Tufts Medical Center
Pamela C. Yelick, PhD, Professor, Department of Oral and Maxillofacial Pathology, Tufts University School of Dental Medicine

TITLE: Zebrafish as a Model for Elucidation of Roles of Angiogenin in ALS

GRANT TYPE: Catalyst

 

Co-PIs: Linden T. Hu, MD, Associate Professor, Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center
Sam R. Telford, ScD, Associate Professor, Department of Biomedical Sciences, Cummings School of Veterinary Medicine

TITLE: Development of a Reservoir Targeted Vaccine for Lyme Disease

GRANT TYPE: Catalyst

 

Co-PIs: Dakshina M. Jandhyala, PhD, Research Associate, Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center
Robert M. Blanton, MD, MA, Assistant Professor, Division of Cardiology, Tufts Medical Center
Cheleste M. Thorpe, Associate Professor, Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center

TITLE: Heart Failure and the Role of Intestinal Dysfunction

GRANT TYPE: Catalyst

 

Co-PIs: John M. Kyriakis, PhD, Professor, Molecular Cardiology Research Institute, Tufts Medical Center
Andrew S. Greenberg, MD, Senior Scientist and Director, Obesity and Metabolism Laboratory, Human Nutrition Research Center on Aging

TITLE: Novel MAPK Pathways in Obesity-Induced Insulin Resistance

GRANT TYPE: Catalyst

 

Co-PIs: Laurel K. Leslie, MD, MPH, Associate Professor, Institute for Clinical Research & Health Policy Studies, Tufts Medical Center
Susan K. Parsons, MD, MRP, Professor, Institute for Clinical Research & Health Policy Studies, Tufts Medical Center
Christopher Bellonci, MD, Assistant Professor, Psychiatry, Tufts Medical Center
Joshua T. Cohen, MA, PhD, Research Associate Professor, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center
John B. Wong, MD, Professor, Clinical Decision Making, Informatics and Telemedicine, Tufts Medical Center

TITLE: Preferences and Practices in Prescribing Antipsychotics for Pediatric ADHD

GRANT TYPE: Catalyst

 

Co-PIs: Robert E. Martell, MD, PhD, Associate Professor, Division of Hematology/Oncology, Tufts Medical Center
Philip N. Tsichlis, MD, Professor, Molecular Oncology Research Institute, Tufts Medical Center

TITLE: Effects of Prospective Metformin Administration on Colon Cancer Stem Cells in Patient Tumors

GRANT TYPE: Catalyst

 

Co-PIs: David E. Thaler, MD, PhD, Associate Professor, Department of Neurology, Tufts Medical Center
Edward Feldmann, MD, Professor, Department of Neurology, Tufts Medical Center
Leonard D’Avolio, PhD, Associate Center Director, Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
Louis Fiore, MD, MPH, Chief, General Medicine and Clinical Epidemiology, VA Boston Healthcare System

TITLE: Dissection in the Veterans Administration

GRANT TYPE: Catalyst

 

Co-PIs: Edouard G. Vannier, PhD, Assistant Professor of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center
Peter J. Krause, MD. Senior Research Scientist and Lecturer, Division of Epidemiology of Microbial Diseases, Yale University School of Public Health
Peter J. Castaldi, MD, Assistant Professor, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center

TITLE: Determinants of Susceptibility to Human Babesiosis, an Emerging Infectious Disease

GRANT TYPE: Catalyst

 

Co-PIs: Irene Georgakoudi, PhD, Associate Professor, Department of Biomedical Engineering, Tufts University School of Engineering
Charlotte Kuperwasser, PhD, Associate Professor, Department of Anatomy and Cellular Biology, Tufts University School of Medicine
Rachel J. Buchsbaum, MD, Assistant Professor, Molecular Oncology Research Institute, Tufts Medical Center

TITLE: Development of a Minimally Invasive Biomarker for Breast Cancer Development and Metastasis

GRANT TYPE: Methods Development

 

Co-PIs: Kari E. Roberts, MD, Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center
Joel A. Wirth, MD, Director, Division of Pulmonary and Critical Care Medicine, Maine Medical Center
Anne Breggia, PhD, Laboratory Manager, Center for Clinical and Translational Research, Maine Medical Center Research Institute

TITLE: Development of a Diagnostic Test for Advanced Glycation End-products in Pulmonary Hypertension

GRANT TYPE: Methods Development

 

Co-PIs: R. Christopher Sheldrick, PhD, Assistant Professor, Division of Developmental-Behavioral Pediatrics, Tufts Medical Center
Ellen C. Perrin, MD, Professor, Division of Developmental-Behavioral Pediatrics, Tufts Medical Center
Steven A. Cohen, DrPH, , Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine

TITLE: Latent Class Analysis for Two-Stage Comparative Effectiveness Studies of Screening Instruments

GRANT TYPE: Methods Development

 

Co-PIs: Fang Fang Zhang, MD, PhD, Assistant Professor, Department of Nutrition Science, Friedman School of Nutrition Science and Policy
Michael J. Kelly, MD, MPH, Assistant Professor, Division of Pediatric Hematology/Oncology, Tufts Medical Center

TITLE: Methods Development for Measuring Energy Intake and Dietary Patterns in Pediatric ALL Survivors

GRANT TYPE: Methods Development

 

Co-PIs: Kari E. Roberts, MD, Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center
Jessica K. Paulus, ScD, Assistant Professor, Tufts Clinical and Translational Science Institute

TITLE: Reproductive Risk Factors in Pulmonary Arterial Hypertension: Unraveling Gender Disparities

GRANT TYPE: Planning

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2012 Pilot Studies Grant Awardees

Twelve projects were awarded in 2012.

 

PI: Miaofen G. Hu, MD, PhD, Assistant Professor, Medicine, Molecular Oncology Research Institute, Tufts Medical Center

Co-PI: Richard A. Van Etten, MD, PhD, Professor, Medicine, Molecular Oncology Research Institute, Tufts Medical Center

TITLE: The Role Of CDK6 In Chronic Myeloid Leukemia

GRANT TYPE: Catalyst

 

PI: Gordon S. Huggins, MD, Associate Professor, Medicine, Molecular Cardiology Research Institute, Tufts Medical Center

Co-PIs: Lauren D. Black III, PhD, Assistant Professor, Biomedical Engineering, Tufts University School of Engineering
Philip W. Hinds, PhD, Professor, Radiation Oncology, Molecular Oncology Research Institute, Tufts Medical Center

TITLE: Basic Mechanisms of Human Calcific Aortic Valve Disease

GRANT TYPE: Catalyst

 

PI: Andreas K. Klein, MD, Assistant Professor, Medicine, Division of Hematology/Oncology, Tufts Medical Center

Co-PI: Raymond L. Comenzo, MD, Lecturer, Pathology, Division of Hematology/Oncology, Tufts Medical Center

TITLE: Characterization of A Naïve T-Cell (CD45RA)-Depleted Stem Cell Graft For Allogeneic Stem Cell Transplant With Reduced Risk For Graft-Versus-Host Disease

GRANT TYPE: Catalyst

 

PI: Jamie L Maguire, PhD, Assistant Professor, Neuroscience, Tufts University School of Medicine

Co-PIs: Julian K. Wu, MD, FACS, Professor, Neurosurgery, Division of Neuro-oncology, Tufts Medical Center
Alain Charest, PhD, MSc, Research Assistant Professor, Neurosurgery, Molecular Oncology Research Institute, Tufts Medical Center

TITLE: Investigating KCC2 As A Novel Target For The Treatment Of Tumor-Associated Epilepsy

GRANT TYPE: Catalyst

 

PI: Benjamin C. Nephew, PhD, Assistant Professor, Biomedical Sciences, Section of Neuroscience and Reproductive Biology, Cummings School of Veterinary Medicine, Tufts University

Co-PI: Christopher Murgatroyd, PhD, Lecturer, Division of Health Science, School of Healthcare Science, Manchester Metropolitan University

TITLE: Oxytocin, Postpartum Depression and Anxiety, and Autism

GRANT TYPE: Catalyst

 

PI: Ksenia N. Tonyushkina, MD, Assistant Professor, Pediatrics, Division of Pediatric Endocrinology, Baystate Medical Center

Co-PI: Rolf O. Karlstrom, PhD, Professor, Biology, University of Massachusetts Amherst

TITLE: Early Life Programming of Thyroid Axis Regulation

GRANT TYPE: Catalyst

 

PI: Daniel E. Weiner, MD, MS, Assistant Professor, Medicine, Division of Nephrology, Tufts Medical Center

Co-PIs: Sergio Fantini, PhD, Professor, Biomedical Engineering, Tufts University School of Engineering
Tammy M. Scott, PhD, Scientist II, Nutrition and Neurocognition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging
Mark J. Sarnak, MD, MS, Professor, Medicine, Division of Nephrology, Tufts Medical Center
Aron Troen, DPhil, Visiting Scientist II, Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging

TITLE: Brain Perfusion and Cognitive Function in Hemodialysis: Effects of Acute Hemodynamic Changes

GRANT TYPE: Catalyst

 

PI: Henry H Wortis, MD, Professor, Pathology, Tufts University School of Medicine

Co-PIs: Alexander N. Poltorak, PhD, Assistant Professor, Pathology, Tufts University School of Medicine
Andrew Camilli, PhD, Professor, Molecular Biology and Microbiology, Tufts University School of Medicine
Clay Bennett, PhD, Assistant Professor, Chemistry, Tufts University School of Arts and Sciences

TITLE: Carbohydrate Antigen-Based Vaccine

GRANT TYPE: Catalyst

 

PI: Nirupa R. Matthan, PhD, Scientist II, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging

Co-PIs: Alice H. Lichtenstein, DSc, Senior Scientist, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging
Sarah L. Booth, PhD, Senior Scientist, Vitamin K. Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging
Kyung-Jin Yeum, PhD, Scientist I, Carotenoids and Health Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging
Judith Wylie-Rosett, EdD, RD, Professor, Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University and Montefiore Medical Center

TITLE: Impact of Acculturation Status on Dietary Patterns and Health Outcomes in Chinese Americans

GRANT TYPE: Methods Development

 

PI: Margie Skeer, ScD., MPH, MSW, Assistant Professor, Public Health and Community Medicine, Tufts University School of Medicine

Co-PIs: Sara C. Folta, PhD, Assistant Professor, John Hancock Research Center, Friedman School of Nutrition Science and Policy, Tufts University
Kendrin R. Sonneville, ScD, Instructor in Pediatrics, Division of Adolescent Medicine, Children’s Hospital Boston

TITLE: Developing An Instrument To Measure Family Meals in Relation To The Prevention Of Adolescent Risk

GRANT TYPE: Methods Development

 

PI: Howard A. Smithline, MD, MS, Associate Professor, Emergency Medicine, Baystate Medical Center

Co-PI: Khalid H. Ismail, MD, Assistant Professor, Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center

TITLE: Validity of Dyspnea Severity Measure in Acute Heart Failure: Pilot Study

GRANT TYPE: Methods Development

 

PI: Philip N. Tsichlis, MD, Professor, Medicine, Molecular Oncology Research Institute, Tufts Medical Center

TITLE: NDY1/KDM2B: Development of An Enzymatic Assay And Initial Screening For Inhibitors

GRANT TYPE: Methods Development

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2013 Pilot Studies Grant Awardees

Two projects were awarded in 2013.

 

PI: Bill Chiu, MD, Assistant Professor, Molecular Oncology Research Institute, Tufts Medical Center

Co-PI: David Kaplan, PhD, Professor, Biomedical Engineering, Tufts University

TITLE: Development of Focal Therapy for Locally Advanced Neuroblastoma

GRANT TYPE: Catalyst

 

PI: Virginia Rall Chomitz, PhD, Assistant Professor, Public Health and Community Medicine, Tufts University School of Medicine

Co-PIs: Carole A. Palmer, RD, EdD, Division Head and Professor, Nutrition and Oral Health Promotion, Tufts University School of Dental Medicine

Cheen Y. Loo, DMD, Director and Associate Professor, Postdoctoral Pediatric Dentistry Program, Tufts University School of Dental Medicine

Susan Koch-Weser, ScD, Assistant Professor, Public Health and Community Medicine, Tufts University School of Medicine

Aviva Must, PhD, Morton A. Madoff Professor, Public Health and Community Medicine, Tufts University School of Medicine

TITLE: Baby Steps to Healthy Eating and Healthy Teeth: A Public Health/Dental Obesity Prevention Pilot

GRANT TYPE: Methods Development

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2014 Pilot Studies Grant Awardees

Eight projects were awarded in 2014.

 

PI: Susan Hadley, MD, Professor, Tufts Medical Center, Geographic Medicine and Infectious Disease

Co-PIs: Eric L. Smith, MD, Assistant Professor, Tufts Medical Center, Orthopedics

Madhumathi Rao, MD, PhD, Assistant Professor, Tufts Medical Center, Nephrology

TITLE: Antibiotic Spacers for Infected Joint Prostheses: A Pilot Study of Antibiotic Levels and Kidney Function

GRANT TYPE: Catalyst

 

PI: Paul Han, MD, Associate Professor and Director of the Center for Outcomes Research and Evaluation, Maine Medical Center

Co-PI: Remco Chang, PhD, Assistant Professor, Tufts University, Computer Science, Visual Analytics Library

TITLE: Development of the Prognosis Assessment for Conservative Treatment (PROACT) Tool

GRANT TYPE: Catalyst

 

PI: Miaofen G. Hu, MD, PhD, Assistant Professor, Tufts Medical Center, Molecular Oncology Research Institute

Co-PI: Andrew Greenberg, MD, Professor, Tufts University, Jean Mayer USDA Human Nutrition Research Center on Aging

TITLE: The Role of CDK6 in Adipogenesis, Obesity and Diabetes

GRANT TYPE: Catalyst

 

PI: Heber C. Nielsen, MD, Professor, Tufts Medical Center, Pediatrics, Neonatology

Co-PI: Li Zeng, PhD, Associate Professor, Tufts University School of Medicine, Integrative Physiology and Pathobiology

TITLE: Modulating PEDF to Treat Osteoarthritis

GRANT TYPE: Catalyst

 

PI: Rachel Buchsbaum, MD, Associate Professor, Tufts Medical Center, Molecular Oncology Research Institute

Co-PI: William Hancock, PhD, Professor, Northeastern University, Chemistry

TITLE: Finding the X Factor: How Breast Cancers Conscript the Tumor Microenvironment

GRANT TYPE: Multi-site Catalyst

 

PI: Daniel Jay, PhD, Professor, Tufts University School of Medicine, Developmental Molecular and Chemical Biology

Co-PIs: Phillip G. Haydon, PhD, Professor and Chair, Tufts University School of Medicine, Neuroscience

Thomas Biederer, PhD, Associate Professor, Tufts University School of Medicine, Neuroscience

TITLE: Gain Or Loss of Function in Neurons and Glia

GRANT TYPE: Methods Development

 

PI: Andreas K. Klein, MD, SM, Assistant Professor, Tufts Medical Center, Division of Hematology/Oncology

Co-PI: Irene Georgakoudi, PhD, Associate Professor, Tufts University, Biomedical Engineering

TITLE: Confocal Backscatter-based Analysis of Circulating Malignant Lymphoid Cells

GRANT TYPE: Methods Development

 

PI: JoAnna K. Leyenaar, MD, MPH, MSc, Assistant Professor, Tufts University School of Medicine, Pediatrics

Co-PIs: Dmitry Khodyakov, PhD, Behavioral/Social Scientist, RAND Corporation

Susan L. Parish, PhD, MSW, Professor and Associate Dean, Brandeis University Heller School for Social Policy and Management

Laurel K. Leslie, MD, MPH, Professor, Tufts Medical Center, Pediatrics, Medicine, and Community Medicine; Tufts CTSI

Peter K. Lindenauer, MD, MSc, Associate Professor, Baystate Medical Center, Center for Quality of Care Research

TITLE: “Nothing About Me Without Me”: Incorporating Patients’ Perspectives in the Discharge Record

GRANT TYPE: Methods Development

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2015 Pilot Studies Grant Awardees

The Tufts CTSI Pilot Studies program prioritizes three of our signature programs, including Stakeholder and Community Engagement.  In the 2015 funding cycle, investigators submitted eight T3-T4 proposals. Five projects were funded including one T3-T4 project:

 

PI: Kieran F. Reid, PhD, MPH, Scientist III, Tufts University, Jean Mayer USDA Human Nutrition Center on Aging

Co-PI: Roger A. Fielding, PhD, Professor and Senior Scientist, Tufts University, Jean Mayer USDA Human Nutrition Center on Aging

TITLE: Translating a physical activity program into the community to preserve mobility in older adults

GRANT TYPE: Signature Programs/Stakeholder & Community Engagement; Single-site; T3

 

PI: Honorine D. Ward, MBBS, Professor, Tufts Medical Center, Division of Geographic Medicine and Infectious Diseases

Co-PI: David R. Walt, PhD, Professor, Tufts University, Chemistry

TITLE: A point-of-care diagnostic platform for cryptosporidiosis

GRANT TYPE: Signature Programs/One Health; Multi-site; T1/T2

 

PI: Alexei Degterev, PhD, Associate Professor, Tufts University School of Medicine, Developmental Molecular and Chemical Biology

Co-PIs: Vladimir P. Torchilin, PhD, Professor and Director, Northeastern University, Center for Pharmaceutical Biotechnology and Nanomedicine

James D. Baleja, PhD, Associate Professor, Tufts University School of Medicine, Developmental Molecular and Chemical Biology

TITLE: Targeting melanoma via induction of synthetic metabolic collapse

GRANT TYPE: Methods Development; Multi-site; T1

 

PI: Howard C. Jen, MD, MSHS, Assistant Professor, Tufts Medical Center, Pediatric Surgery

Co-PI: David Kent, MD, Professor, Tufts Medical Center, Institute for Clinical Research and Health Policy

TITLE: Enhancing patient centered decision-making prenatally through creation of a prediction model of CDH outcomes

GRANT TYPE: Methods Development; Single-site; T2

 

PI: Donna Slonim, PhD, Associate Professor, Tufts University, Computer Science

Co-PI: Diana W. Bianchi, MD, Professor, Tufts Medical Center, Mother Infant Research Institute

TITLE: Identifying treatments for fetuses and neonates with developmental disorders through data mining

GRANT TYPE: Methods Development; Multi-site; T1

 

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2016 Pilot Studies Grant Awardees

In the 2016 funding cycle, investigators submitted 13 T3-T4 proposals. A total of six projects were funded including three T3-T4 projects:

 

PI: Jessica Paulus, ScD, Investigator, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; Assistant Professor of Medicine, Tufts University School of Medicine

Co-PI: Arlin Rogers, DVM, PhD, Associate Professor, Tufts University Cummings School of Veterinary Medicine

TITLE: Prolactin as a chemopreventive strategy for hepatocellular carcinoma

GRANT TYPE: Signature Programs/Comparative Effectiveness Research; Multi-site; T1/T2

 

PI: Marieke Rosenbaum, DVM, MPH, Research Assistant Professor of Public Health and Community Medicine, Tufts University Cummings School of Veterinary Medicine

TITLE: Lead and Salmonella in urban poultry flocks in Boston: Evaluating backyard chickens as sentinels of environmental contamination and vehicles for human exposure

GRANT TYPE: Signature Programs/One Health; Single-site; T3/T4

 

PI: Thomas Stopka, PhD, MHS, Assistant Professor of Public Health and Community Medicine, Tufts University School of Medicine

Co-PIs: Leo Beletsky, JD, MPH, Associate Professor, Northeastern University Bouve College of Health Sciences

Peter Kreiner, PhD, Senior Scientist, Brandeis University Schneider Institute for Health Policy

TITLE: Facing the Opioid Epidemic (FOE): Assessing and responding to prescription and illicit opioid use and misuse in five New England states

GRANT TYPE: Multi-site; T4

 

PI: Amanda Vest, MD, MPH, Cardiologist, Tufts Medical Center; Assistant Professor of Medicine, Tufts University School of Medicine

TITLE: Is Cardiac Cachexia reversible after implantation of a left ventricular assist device in patients with Advanced Systolic Heart Failure?

GRANT TYPE: Single-site; T3

 

PI: Amy Yee, PhD, Professor of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine

Co-PI: Jatin Roper, MD, Director, Center for Hereditary Gastrointestinal Cancer, Tufts Medical Center; Assistant Professor, Tufts University School of Medicine

TITLE: A Pre-clinical model of Colitis-associated Colorectal Cancer

GRANT TYPE: Methods Development; Multi-site; T1

 

PI: Emily Zimmerman, PhD, Director, Speech and Neurodevelopment Lab, Department of Speech-Language Pathology and Audiology, Northeastern University

Co-PI: Jill Maron, MD, MPH, Neonatologist, Tufts Medical Center; Associate Professor, Tufts University School of Medicine

TITLE: FOXP2 gene expression levels: A noninvasive biomarker to predict both oral feeding and speech-language success

GRANT TYPE: Signature Programs/Comparative Effectiveness Research; Multi-site; T1

 

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2017 Pilot Studies Grant Awardees

Tufts CTSI’s Pilot Studies Program prioritizes translational research projects in five areas, including three signature programs (Stakeholder and Community Engagement, Comparative Effectiveness Research, One Health), Integrating Special Populations, and Methods Development. In the 2017 funding cycle, investigators submitted ten T3-T4 proposals. Six projects will be funded including three T3-T4 proposals.

PI: Linda Hudson, ScD, ScM, MSPH, Assistant Professor, Public Health and Community Medicine, Tufts University School of Medicine

Co-PI: Sara Folta, PhD, Assistant Professor, Friedman School of Nutrition Science and Policy, Tufts University

TITLE: Examining the efficacy of a culturally appropriate cardiovascular disease (CVD) prevention curriculum designed for African-American women

Grant Type: Integrating Special Populations; Single-site; T4

 

PI: Tania Konry, PhD, Assistant Professor, Pharmaceutical Science, Northeastern University

Co-PI: Andrew Evens, DO, MSc, Director of Tufts Cancer Center, Tufts Medical Center

TITLE: Determining antibody treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platforms

Grant Type: Methods Development; Multi-site; T1

 

PI: Danielle Levac, PhD, Assistant Professor, Bioengineering, Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University

Co-PI: Nathan Ward, PhD, Assistant Professor, Psychology, Tufts University

TITLE: Influence of virtual environment complexity on motor learning in children with cerebral palsy: Implications for virtual reality use in rehabilitation

Grant Type: Signature Program (Comparative Effectiveness Research); Multi-site; T2

 

PI: Alisa Lincoln, PhD, MPH, BA/BS, Professor, Health Sciences and Sociology, Northeastern University

TITLE: Literacy Education for Improving Engagement In Treatment and Community Inclusion for People with Serious Mental Illness

Grant Type: Signature Program (Stakeholder and Community Engagement)/ Integrating Special Populations; Single-site; T2-T3

 

PI: Mary Ann Volpe, MD, Associate Professor, Pediatrics and Public Health, Tufts Medical Center

Co-PIs: Jill Maron, MD, MPH, Associate Professor, Pediatrics, Tufts Medical Center; Anjali Iyengar, MD, Assistant Professor, Pediatrics, Tufts Medical Center; Jared Auclair, PhD, Director, Biotechnology Professional Science Masters and Training, Chemistry and Chemical Biology, Northeastern University; Tom Pochapsky, PhD, Professor, Chemistry, and Biochemistry, Brandeis University

TITLE: Development of Microfluidic Platforms to Non-Invasively Predict BPD and BPD-Associated Pulmonary Hypertension in Premature Neonates\

Grant Type: Integrating Special Populations/ Methods Development; Multi-site; T1

 

 

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